Example image of eyePlorer eyePlorer map for 'Panama Canal': Caribbean Sea Pacific Ocean Ship canal Cape Horn Drake Passage Engineering Shipping South America New York City San Francisco Ship French Third Republic United States Landslide Malaria Yellow fever Yacht Panamax Isthmus Bridge of the Americas Charles V, Holy Roman Emperor Isthmus of Panama Peru Alessandro Malaspina Panama Darien scheme Kingdom of Scotland Trade route Panama Canal Railway Suez Canal Colombia Ferdinand de Lesseps France Geology Hydrology Mosquito Vector (epidemiology) Nicaragua Momotombo Caribbean Nicaragua Canal The New York Sun United States Senate 1903 Hay–Herran Treaty January 22 John Hay United States Secretary of State Lease March 14